Problem
Some major Windows updates tend to break VirtualBox setup and make Genymotion Desktop no longer usable.
Solution
The best solution is to uninstall and re-install VirtualBox by performing the following steps.
1. Uninstall VirtualBox. 2. Reboot your PC. 3. Download the VirtualBox recommended version installer from the VirtualBox recommended versions article. 4. Re-install VirtualBox. 5. Reboot your PC. 6. Launch Genymotion and start a device.