What hardware specifications are needed to run Genymotion smoothly?

Last verified against genymotion.com:

Genymotion Desktop does not list specific minimum CPU, memory, or graphics card requirements. It only states that Genymotion Desktop needs to run on real hardware and cannot be used in a virtual machine, cloud host, server, Docker, or VPS.

Related pages: Can Genymotion Desktop run in a virtual machine? and Can I use Genymotion Desktop remotely?; remote use also requires a remote access tool that supports OpenGL 3.0+.