Can Genymotion run an apk i want?

Yes, but only if the APK is compatible with the device image you use. If it fails to install or run, the usual causes are root detection, architecture mismatch, or unsupported features.

Use a non-rooted image when possible, and check whether the app is ARM-only or needs features Genymotion does not emulate, such as Bluetooth or sensors. On Desktop, APKs that trigger INCOMPATIBLE_ABI often need an arm64-capable setup like Mac M or SaaS arm64 devices. Sources: I can't install my application with an APK file, I can't install or run an application/game in Genymotion Desktop, Install Applications