Does Genymotion Desktop require VirtualBox, and on which OS is it supported?

High Confidence (78%)
VirtualBox integration with Genymotion Desktop

Genymotion Desktop relies on VirtualBox as the default hypervisor on Windows, while QEMU is the recommended hypervisor on Linux and macOS. VirtualBox is not required on macOS or Linux and is unsupported on Windows 10.

Genymotion Desktop Release Notes | Genymotion Desktop and standard (non admin) user accounts on Windows

What specific task are you trying to accomplish with VirtualBox and Genymotion?