What the different between with virtual box and without virtual box?

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Genymotion Desktop uses VirtualBox as the default hypervisor on Windows, providing the officially supported and stable environment but requiring a compatible GPU and disabled Hyper‑V What are Genymotion Desktop requirements?.

Choosing to run without VirtualBox means switching to the experimental QEMU hypervisor; on Windows this also requires Hyper‑V and can suffer performance and stability issues, while on Linux/macOS QEMU is the recommended default What are Genymotion Desktop requirements?.